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Exploring Lysergamides (lsd family origins): A Comprehensive Guide. What is LSD & its origins

Exploring Lysergamides what are Lysergamides and what is LSD?

Lysergamides, a fascinating class of psychoactive substances, have gained significant attention for their unique effects on the human mind. With a chemical structure similar to lysergic acid diethylamide (LSD), lysergamides offer an intriguing alternative for individuals interested in exploring altered states of consciousness. In this article, we will delve into the world of lysergamides, uncovering their definition, history, effects, and potential applications.

Section 1: Understanding Lysergamides

1.1 Definition of Lysergamides:

Lysergamides are a class of organic compounds characterized by a shared core structure, consisting of a lysergic acid backbone. They typically act as psychedelic substances, influencing perception, cognition, and emotions.

1.2 Origins and History:

The discovery of lysergamides can be traced back to the early 20th century when Albert Hofmann first synthesized LSD in 1938. Since then, various analogs and derivatives of LSD have been developed, collectively known as lysergamides. However, the precursor for LSD, lysergic acid, is derived from a naturally occurring compound called ergotamine. Ergotamine is found in the ergot fungus, primarily Claviceps purpurea, which commonly infects rye and other cereal crops. This fungus replaces the grain's kernel and produces ergot alkaloids, including ergotamine.

Ergotamine itself is chemically similar to another compound called lysergic acid amide (LSA), which is naturally found in various seeds, including those of morning glory (Ipomoea tricolor) and Hawaiian baby woodrose (Argyreia nervosa). These seeds have been used traditionally by certain indigenous cultures for their psychoactive properties. LSA shares a structural resemblance to LSD and exhibits psychedelic effects, albeit with a milder potency and slightly different experience. LSA contains Ergot alkaloids just like in Ergot fungus.

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Building upon the knowledge of ergot alkaloids and their effects, Hofmann synthesized LSD by modifying the lysergic acid molecule. Through a series of chemical transformations, including the addition of diethylamide, LSD was created. Hofmann accidentally discovered its potent effects during his initial synthesis and later intentionally experimented with LSD, leading to the famous bicycle ride and his subsequent research on its psychoactive properties.

The correlation between LSD and LSA lies in their chemical structures and psychoactive effects. Both compounds belong to the lysergamide family and share a common lysergic acid backbone. While LSA occurs naturally in certain seeds and provides psychedelic experiences, LSD, synthesized from ergotamine, is known for its profound and intense effects on consciousness. The synthesis and understanding of LSD and its relationship to natural compounds like ergotamine and LSA have contributed to the exploration of altered states of mind and the advancement of psychedelic research.

Section 2: Lysergamides and Their Effects

2.1 Psychoactive Properties:

Lysergamides interact with the serotonin receptors in the brain, primarily targeting the 5-HT2A receptors. This interaction leads to altered sensory perception, enhanced cognition, emotional shifts, and profound introspection. The subjective effects of lysergamides may include visual hallucinations, intensified colors, synesthesia, and a sense of connectedness.

2.2 Dosage and Duration:

The potency and duration of lysergamides can vary depending on the specific compound. Generally, they are consumed orally, and the effects onset within 30 to 90 minutes, peaking at around 2 to 4 hours, and lasting up to 8 to 12 hours.

2.3 Safety Considerations:

While lysergamides are considered relatively safe when used responsibly, it is crucial to be aware of potential risks. These substances may induce powerful experiences that can be emotionally challenging or overwhelming for some individuals. Therefore, a controlled set and setting are essential to minimize the risks associated with their use.

Section 3: Popular Lysergamides and Their Applications

3.1 1P-LSD:

1P-LSD, a popular lysergamide, is structurally similar to LSD and known for its psychedelic properties. It has gained popularity among researchers and psychonauts alike for its potential in exploring consciousness, personal growth, and introspection.

3.2 AL-LAD:

AL-LAD is another lysergamide that has garnered interest due to its unique effects. Often described as a less intense and more visual alternative to LSD, AL-LAD offers a distinctive psychedelic experience, making it appealing to those seeking artistic inspiration or recreational exploration.

3.3 Research Potential:

Apart from recreational and spiritual uses, lysergamides have attracted scientific attention for their potential in therapeutic applications. Preliminary research suggests that they may hold promise in treating certain mental health conditions such as anxiety, depression, and post-traumatic stress disorder (PTSD). However, further studies are needed to fully understand their therapeutic potential.


Lysergamides represent a captivating realm of psychoactive compounds that offer profound experiences and unique perspectives on human consciousness. With their effects ranging from sensory alterations to emotional insights, lysergamides continue to intrigue researchers, therapists, and curious individuals alike. As with any psychoactive substance, it is essential to approach lysergamides with caution, respecting their power and potential risks. Whether for personal growth, scientific exploration, or recreational use, lysergamides present a captivating avenue for those fascinated by the depths of the human mind.

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